 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
The treatment of substrates such as alcohols, phenols and amines with acetic anhydride (or acetyl chloride) in the presence of pyridine has provided a general acetylation method since the turn of the 20th century. However, this approach often proves to be unsatisfactory for the acetylation of deactivated substrates. It was not until the late 1960’s that certain 4-dialkylaminopyridines were found (independently by two research groups) to be much superior to pyridine as catalysts for difficult acetylations or acylations, in general.
4-Dialkylaminopyridines were soon found to have general applicability for catalysis of a wide variety of reactions. The subject of 4-Dimethylaminopyridine’s (DMAP) wide applicability has been frequently reviewed since the first review appeared in 1978 (1-5). The accelerating pace of reported applications for DMAP and the availability of EASY-FLO® DMAP in large quantities, at modest prices, has continued to stimulate great interest in its use as a catalyst in the fields of organic, polymer, analytical and biochemistry. Today there are thousands of examples of the use of DMAP in far ranging fields of chemistry in both patents and the research literature. Many full-scale production processes utilizing DMAP have been and are being operated and many pharmaceutical and agricultural products that rely on DMAP’s superior catalytic properties in their manufacture have been produced for years.
In addition, Reilly's introduction of EASY-FLO® DMAP in answer to requests from customers using DMAP in commercial scale equipment has made its handling safer and easier, particularly when it must be introduced to closed systems. To reduce costs and enhance safety while using Reilly's EASY-FLO® DMAP, you can order it custom packaged to your precise weight and packaging specifications.
The research and engineering staffs at Reilly Industries, the world leader in DMAP production and sole supplier of EASY-FLO® DMAP, present this Web site for you and your colleagues engaged in research, in scale-up and in production. It is a collection of examples from the literature in which DMAP has been used effectively to improve, and in some cases make possible, transformations in organic chemistry and in efficient production of commercial products. It is our fond hope that collecting these examples and presenting them in this easily accessible format will make your job easier and more effective as you search for ways to synthesize new molecules, for ways to commercialize new materials or for ways to improve existing production processes.
We would like to continue to help you. We have accumulated many years of experience working with customers using EASY-FLO® DMAP in a vast array of different applications. We'd like to share that experience with you whether in a research or production setting. Please call us, click here or click on the appropriate link below.
Thank you.
Hofle, G.; Steglich, W.; Vorbrueggen, H. Angew. Chem. Int. Ed. Engl. 1978, 17, 569.
Scriven, E. F. V. Chem. Soc. Rev. 1983, 12, 129.
Hassner, A. in Encyclopedia of Reagents for Organic Synthesis.
Paquette, L. A., Ed.; Wiley, Chichester, 1995; pp 2022.
Ragnarsson, U.; Grehn, L. Acc. Chem. Res. 1998, 31, 494.